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Difference Between WES and WGS

WES and WGS are both NGS methods with different coverage and applications.

Educational Articles

Introduction

The right choice between WES and WGS depends on the clinical question.

WES

Protein-coding regions only; lower cost.

WGS

Entire genome; detects structural variants.

Which to choose?

WES is usually first-line; WGS for complex or research cases.

Frequently Asked Questions

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Gene Negar Ayandegan · Difference Between WES and WGS