What is male infertility?
Impaired sperm production or transport.
Symptoms
Azoospermia, severe oligospermia, partner's recurrent miscarriage.
Genetic causes
Y chromosome microdeletion, abnormal karyotype, CFTR.
Inheritance pattern
Depends on the gene.
Important genes
AZF (Y), CFTR, chromosomes.
Who should be tested?
Men with severely abnormal semen analysis before IVF/ICSI.
Recommended tests
Y microdeletion, karyotype, CFTR analysis.
Counseling
Discussion of ART and transmission risk to offspring.