Is thalassemia curable?

Bone marrow transplant can be curative in select cases but is not suitable for all patients.

What is the risk for a child of two carriers?

25% chance of thalassemia major in each pregnancy.

Genetic Diseases

Thalassemia is the most common inherited blood disorder in Iran; carrier screening plays a key preventive role.

An inherited disorder of hemoglobin chain synthesis, causing chronic anemia.

Severe anemia, growth delay, splenomegaly and regular transfusions in the major form.

Mutations in HBB (beta) or HBA1/HBA2 (alpha) genes.

Autosomal recessive.

HBB, HBA1, HBA2.

Couples before marriage, relatives of patients and individuals with low MCV.

Carrier screening, HBB sequencing, MLPA for alpha.

PGT-M offers carrier couples an important option to prevent affected pregnancies.

Contact Gene Negar Ayandegan for sample submission, laboratory collaboration, or more information.