Cancer Genetics

Colorectal Cancer Genetics

About 5% of colorectal cancers have a known hereditary basis.

Cancer Genetics

Overview

Common syndromes such as Lynch and FAP are key hereditary drivers.

When is it hereditary?

Young onset, multiple polyps, strong family history.

Important genes

MLH1, MSH2, MSH6, PMS2, APC, MUTYH.

Recommended tests

Hereditary cancer panel, tumor MSI/IHC testing.

Who should be tested?

Per Bethesda or Amsterdam criteria.

Benefits for family

Early colonoscopy screening and mortality reduction.

Frequently Asked Questions

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