Overview
Common syndromes such as Lynch and FAP are key hereditary drivers.
When is it hereditary?
Young onset, multiple polyps, strong family history.
Important genes
MLH1, MSH2, MSH6, PMS2, APC, MUTYH.
Recommended tests
Hereditary cancer panel, tumor MSI/IHC testing.
Who should be tested?
Per Bethesda or Amsterdam criteria.
Benefits for family
Early colonoscopy screening and mortality reduction.