What is RPL?
Two or more consecutive pregnancy losses.
Symptoms
Repeated first-trimester pregnancy loss.
Genetic causes
Fetal aneuploidy, balanced parental translocations.
Inheritance pattern
Depends on the cause.
Important genes
Variable.
Who should be tested?
Couples with RPL and, when available, products of conception.
Recommended tests
Parental karyotype, QF-PCR or microarray on POC, PGT-A.
Counseling
Prenatal options and PGT-A in future pregnancies.